Endogenous Mechanisms of Neuroprotection and Neuroregeneration

481 Fom the point of view of oligodendrocyte and demyelinated axon interaction, glial scars of reactive astrocytes obstruct to myelinating oligodendrocytes the access to naked axons. On the other hand, astrocytes also produce neurotrophic factors that promote remyelination. An alternative strategy that CNS cells have to avoid axonal damage, when remyelination is not efficient, consists in that either oligodendrocyte or astrocyte processes sheath the denuded axons. Although the CNS have endogenous mechanisms to promote myelin repair, more often remyelinated lesions may even become the target of new demyelinating attacks 60 difficulting the neuroregenerative process.